If safflower oil is used for the topical treatment of acute limb injury, it needs to be used at least 48h later, if it is used for the treatment of rheumatism and bone disease, etc. it can be used immediately. Safflower oil is a topical drug that activates blood circulation and removes blood stasis, and it is not recommended to be used during the acute attack of limb injury. If used immediately after injury, it is very easy to cause limb swelling and increased pain, and is recommended to be used 48h after injury to promote limb swelling and pain subside. If safflower oil is used to treat diseases such as chronic rheumatism and bone disease, safflower oil can be used immediately along with the pain.