There are various reasons for bitter mouth in the middle of the night, such as damp-heat of liver and gallbladder (damp-heat evils accumulated in the liver and gallbladder), Yin deficiency and fire exuberance (deficiency of Yin essence in the body and hyperactivity of deficiency and fire), stomach fire blazing, etc. According to the different symptoms, you can choose the appropriate medicines, such as Longdian Diarrhea Liver Pill, Zhibai Di Huang Pill, Niu Huang Qing Stomach Pill and so on. 1. The treatment of those with liver and gallbladder dampness-heat is mainly to clear the liver and gallbladder dampness-heat, and the medicines to choose from are Longdian Diarrhea Liver Pill, Jaundice Yin Chen Granules and so on. 2. The treatment of those with yin deficiency and fire exuberance mainly focuses on nourishing yin and clearing heat (nourishing yin essence and clearing heat), and the drugs available are Zhi Bai Di Huang Wan, Qi Ju Di Huang Wan, and so on. 3. Stomach fire blazing person treatment mainly to clear diarrhea stomach fire mainly, may choose the medicine has the cattle yellow clear stomach pill, gardenia gold flower pill and so on. The middle of the night bitter mouth is recommended to go to the regular hospital in a timely manner, need to be in the professional doctor’s evidence under the guidance of medication, should not be self-medication, so as not to delay the condition.