Lowering blood pressure is the core element to ensure good control of blood pressure and reduce cardiac, cerebral and renal complications. Medication is the main measure, but “medicine is poisonous” is also a real problem that cannot be avoided. In clinical work, we often encounter some hypertensive friends in the standard and drug side effects of the problem of confusion, some even exaggerate the side effects of antihypertensive drugs, do not take drugs according to medical advice or stop the drug, resulting in blood pressure has not reached the standard, although taking antihypertensive drugs, but still occurred in stroke, heart failure and other serious diseases, resulting in lifelong regret. We need to know what is more important than the other, and we need to understand the importance of lowering blood pressure from a subjective or objective point of view. First of all, let’s talk about what is “lowering blood pressure to the standard”. As the name implies, it means to control blood pressure below a reasonable target value in order to reduce the damage caused by elevated blood pressure. Due to differences in age, gender, genetics and individual differences, the normal blood pressure value for each person at different ages is different, but most people have a reasonable blood pressure value (target blood pressure), within this reasonable blood pressure value, the body’s organ function and structure are in a normal state. This target blood pressure is not set in stone, with the continuous research on hypertension, many large clinical trial results have been published, the target blood pressure since 1977 to the present, the United States, Europe and China to develop the target blood pressure is still constantly revised and adjusted, for example: 1977 ~ 1980 target blood pressure ≤ 160/95mmHg, 2003 target blood pressure <140/ 90mmHg, 2014 target blood pressure <140/90mmHg, and age ≥60 years, its value ≤150/90mmHg. Second, historical events change our view of hypertension. Shortly after the end of World War II, U.S. President Roosevelt died of a sudden cerebral hemorrhage, and Stalin, the former General Secretary of the Central Committee of the Communist Party of the Soviet Union, died of a cerebral hemorrhage due to hypertension in 1953. The sudden death of these two great men shocked the world and caused great concern about the cause of their deaths, and it was discovered that both great men suffered from severe hypertension and did not use measures. It was then realized that hypertension can also kill people without treatment. Because before that, the medical community generally believed that hypertension was a natural phenomenon, a benign disease that could heal itself and did not require aggressive antihypertensive treatment. Third, the history of hypertension treatment. It was only from the 1950s that the medical profession began to pay attention to the control of hypertension, because the number of patients with hypertension was increasing, and strokes, heart failure and kidney failure caused by hypertension were becoming more common. It was the discovery of the first safe and effective antihypertensive drug, chlorothiazide, by Beyer, that made the treatment of hypertension a realistic and feasible thing. This was a landmark event that made long-term effective blood pressure control possible for patients with hypertension. It was not until the late 1970s and early 1980s, when renin angiotensin-converting enzyme inhibitors (ACEI), calcium antagonists (CCB), and highly selective beta-blockers were introduced and used in the treatment of hypertension, that spring truly arrived in the field of hypertension. Fourth, the benefits of lowering blood pressure to achieve the standard. The idea of lowering blood pressure to the standard can be compared to eating apples. Apples are a kind of fruit that can be eaten by young and old, women and children, and can be eaten in all seasons, with rich vitamin content and high nutritional value. Research has proven that apples have different nutritional values at different times of the day, "eating in the morning is gold, eating at noon is silver, eating at night is copper. The results of clinical experiments show that early blood pressure is gold, later is silver, and not is copper, so the idea of lowering blood pressure is the same as eating apples at different times. Frammgham in the United States is recognized as the most systematic and rigorous research project in the world, it began in the 1960s to study whether antihypertensive treatment can reduce the damage to the heart, brain, kidneys and other organs, after more than half a century of systematic research concluded that: active and effective control of good blood pressure can greatly reduce the incidence of stroke, coronary heart disease, heart failure, renal insufficiency, can significantly improve hypertension patients' quality of life and prolong their life expectancy with long-term medication, which can lead to a healthy life. Evidence-based medicine from the 1990s, is a landmark research method in the history of medicine, completely changed the past mainly based on animal testing, laboratory indicators as the end point of the method of judging the efficacy of the clinical data are detailed and reliable, the conclusions have a promotional significance, up to now, a large number of research results confirm that lowering blood pressure can effectively reduce the heart, brain and kidney damage caused by hypertension. "Lowering blood pressure is the hard truth, and lowering blood pressure to achieve the standard is the core". In addition, decades of practice tell us that "early blood pressure lowering, early benefit; sustained blood pressure lowering, sustained benefit; blood pressure lowering up to standard, more benefit" is already an indisputable fact. Fifth, about the side effects of antihypertensive drugs. Antihypertensive drugs have been in use for more than 30 years, and hundreds of millions of hypertensive patients worldwide are taking them, and no serious side effects have been reported. The most widely circulated fallacies are that "antihypertensive drugs are addictive" and "antihypertensive drugs can cause renal insufficiency and uremia". The so-called "addiction" is the need to use the drug, not to take the drug will occur withdrawal, dependence phenomenon, the patient will be very painful, while the current antihypertensive drugs used can completely replace each other, blood pressure can also stop or reduce the amount of normal, there is no "addiction" of the side effects. The side effects of "addiction" do not exist. Statistics from the United States and China show that the main causes of chronic renal insufficiency are hypertension, diabetes and atherosclerosis. In 2013, a group of statistics on renal failure showed that about 25% of chronic renal insufficiency is caused by hypertension. Moreover, many countries in the world and China have carried out case registration systems for hemodialysis, peritoneal dialysis, and kidney transplantation, so that patients with chronic renal failure and uremia are registered, and the causes and incidence can be accurately counted, and there is no finding and evidence that long-term use of antihypertensive drugs can lead to renal insufficiency or uremia. The most convincing example is that Professor Hou Fanfan, a member of the Chinese Academy of Sciences, led her team to systematically study the prevention and treatment of chronic kidney disease and its complications through more than twenty years of unremitting efforts, applying the most commonly used antihypertensive drug Benazepril (renin angiotensin-converting enzyme inhibitor, ACEI) to treat chronic renal insufficiency, achieving significant efficacy and safety without the occurrence of serious side effects, and her research results won the The research results won the National Award for Scientific and Technological Progress, and its paper "Study on the Efficacy and Safety of Benazepril in Advanced Chronic Renal Insufficiency" was published in the New England Journal of Medicine, the highest level journal in the field of medicine, and received unanimous praise from experts at home and abroad, and the journal also issued an editorial commenting that the evidence-based clinical trial changed our traditional concept of prohibiting renin angiotensin-converting enzyme inhibitors in chronic kidney disease and changed our understanding of chronic kidney disease. The journal also commented in an editorial that the evidence-based clinical trial has changed our understanding of chronic kidney disease and opened up a new field of treatment for kidney disease. Some antihypertensive drugs have been found to have serious adverse effects in the course of use and have been gradually banned. For example, long-term use of reserpine can cause gastric ulcers and depression; guanethidine can cause severe hypotension, vertigo, and even syncope, and has been eliminated. The five major classes of antihypertensive drugs in common use now have clear pharmacological effects, mild and reversible side effects, and their safety and effectiveness have been fully verified in decades of clinical practice. To sum up, lowering the blood pressure standard is an important measure to reduce the complications of hypertension, and the side effects of antihypertensive drugs are controllable and reversible. As long as you choose antihypertensive drugs reasonably, control your weight, blood lipids and blood sugar, and develop a good lifestyle, you can reduce the damage of hypertension to the human body. The side effects of drugs and not take drugs or less drugs, because of the small loss, pick up the sesame seeds, lost the watermelon, resulting in lifelong regret. The evidence speaks for itself, not hearsay, which can lead to illness.