Treatment of hypertension includes a healthy lifestyle and medication. A healthy lifestyle is the foundation and essential first step in the treatment of hypertension, and treatment lacking this is incomplete, flawed, and can make the treatment of hypertension difficult. Medication is very important, but what is the proper use of medication for hypertension treatment? When every hypertensive patient sees a doctor for the first time, I think the first question will be, “What is the best medication for me to take?” . This brings us to the question of how you should personally choose your medication, i.e., the rational use of medication. To answer this question, we must first know that hypertension is complex and caused by a variety of factors, such as age, genetics, lifestyle, work stress, environment, etc. This is one of its complex causes. In addition, each patient with hypertension has different concomitant conditions, such as high blood lipids, obesity and other multiple risk factors, some have heart disease, diabetes or cerebrovascular disease, and others have other organ damage, which require doctors to consider treating hypertension and treating the comorbidities at the same time, and each person’s response to medication is very different. All of these factors make the treatment of hypertension more difficult and are the reason why doctors have to choose the right medication. The five major classes of hypertensive drugs can be divided into five categories: diuretics, calcium antagonists (CCB), beta blockers, angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists (ARB). The main goal of treatment is to reduce the overall risk of cardiovascular and cerebrovascular diseases caused by high blood pressure, and only by achieving the standard can we protect the vital organs of the whole body and thus prolong life. All patients with hypertension should have their blood pressure reduced to at least 140/90 mmHg (systolic/diastolic) or lower if tolerated. In the case of patients with diabetes, stroke, myocardial infarction, renal insufficiency, and proteinuria, for which we call them high-risk patients, blood pressure should also be lowered to an even lower target level of 130/80 mmHg or less. If the light medication does not reach the target, it will not play a protective role. 2. Individualized treatment: As mentioned above, each patient with hypertension may have different causes and different concomitant conditions, and it is important to choose different treatment plans depending on the individual to improve the quality of treatment. According to many large-scale studies, we know that each class of antihypertensive drugs has its different therapeutic advantages, i.e., different antihypertensive drugs have different organ-protective effects, such as β-blockers, ACEI and ARB for patients after myocardial infarction, diuretics, β-blockers, ACEI and ARB for patients with heart failure, ACEI and ARB for patients with diabetes, and CCB, ACEI and ARB, such as and so on all require very specialized medical knowledge, should be made by a specialist to make a reasonable choice. 3, the combination of drugs: because of the diversity of causes of hypertension, as well as the additional difficulty of the treatment of hypertension in the elderly, any kind of antihypertensive drugs, monotherapy can only make a small number of patients’ blood pressure standard, in order to make blood pressure down to the target level, most patients need to apply two or more kinds of drugs. For example, diuretics can reduce potassium in the blood, while ACEI or ARB can increase potassium in the blood, and the combination can offset the side effects of the two drugs, which can be said to complement each other’s strengths and thus improve patients’ compliance with the medication. Of course, the reasonable combination of drugs is the specialty of the specialist. 4, reasonable use of other aspects of medication also include: it is desirable to choose the antihypertensive effect lasts 24 hours, once a day to take antihypertensive drugs, so that the blood pressure of 24 hours a day can be effectively controlled, called smooth antihypertensive, which also makes antihypertensive treatment more simplified, not easy to miss the medication, and the price of a suitable drug is also each patient needs to consider, because antihypertensive treatment more lifelong treatment. Hypertensive patients can also have a high quality of life and prolong life as long as they are treated reasonably, which, I think, is what every hypertensive patient wants.