When the disease is well controlled and the hormones are gradually and slowly stopped on the advice of the doctor, there may not be any obvious reaction. When the hormones are suddenly stopped, such as when glucocorticosteroids are stopped, rebound phenomenon, adrenal cortical atrophy, and insufficiency of function may occur. When using hormones to treat the disease, it is not recommended to stop the drug abruptly, should follow the doctor’s advice to gradually reduce the amount of slow stop. When using hormone drugs for glucocorticoid drugs such as cortisone, prednisone, etc., suddenly stopping the drug or reducing the dosage too quickly may appear rebound phenomenon, resulting in relapse or deterioration of the disease, long-term application of the drug may also trigger the medical origin of adrenocortical atrophy and functional insufficiency. Hormonal drugs should be used strictly under the guidance of a doctor and should not be discontinued at will.