Drugs for the treatment of rheumatoid arthritis need to be taken consistently over a long period of time, but which drug is suitable for a specific patient needs to be considered according to the patient’s condition. If the patient applies a certain drug treatment effect is not good, and can not control the rheumatoid arthritis disease activity, you need to adjust the drug. Some patients are in the process of taking medication side effects of drugs, also need to adjust the drug. Commonly taken medications for rheumatoid include methotrexate, hydroxychloroquine, leflunomide, tretinoin, salazosulfapyridine, and Edexin. During the period of taking methotrexate, you need to monitor the changes of blood routine, liver function, etc. If the patient has no serious adverse reactions, methotrexate can be taken for a long time. Next is hydroxychloroquine, liuzasulfapyridine, leflunomide, etc. If the patient has no complications during the application of the above drugs and the therapeutic effect has reached a satisfactory level, he can insist on taking it for a long period of time, and go to the hospital every 2-3 months on average to review the blood routine, liver function, etc. to assess whether there are any adverse reactions to the drugs.