The gastrointestinal tract, as one of the body’s excretory organs, is also an important channel for the body’s metabolites and toxins to be excreted from the body. After daily protein intake, 75% of metabolites and toxins are excreted from the kidneys and 25% are excreted from the intestines. In chronic renal failure, the amount of intestinal toxin excretion from 25% of the total amount of normal to 80%, especially blood creatinine, urea nitrogen secretion to the intestinal lumen of the content of the significantly higher, which for the treatment of the disease of traditional Chinese medicine colonic enema provides a theoretical basis. The Chinese medicine colon enema utilizes the physiological characteristics of the colon, uses the human body’s own intestinal wall as the dialysis membrane, imitates the principle of peritoneal dialysis and is designed to achieve the therapeutic purpose of eliminating the metabolic wastes accumulated in the body, correcting the disturbance of the electrolyte balance, eliminating the excess water in the body, improving the disturbance of the patient’s internal environment, and reducing the lungs and cardiovascular complications by dispersion and osmosis. Gastrointestinal mucosa has semi-permeable membrane characteristics, with selective absorption and excretion. Intestinal administration can stimulate the intestinal mucosa, increase capillary permeability, so that the body of nitrogen and other poisons with intestinal secretion out of the body; but also accelerate the excretion of food residues, inhibit the growth of intestinal flora, thereby reducing the proteolytic decomposition in the intestinal lumen, so that intestinal origin of nitrogen is reduced. Therefore, colonic enema is especially suitable for patients with early and middle stage renal failure. Chinese medicine colon enema can also be through the lungs and large intestine, the lungs are the main qi, towards the function of the hundred veins, there is the role of transporting the essence and other substances to moisten the five viscera and six bowels, limbs and bones, the liquid with the qi and blood dispersed throughout the body, to play a holistic therapeutic effect. Colon enema therapy not only integrates the strengths of modern medicine advanced therapy, but also exerts the systemic regulation and therapeutic effect of Chinese medicine, which changes the inadequacy of the traditional Chinese medicine retention enema therapy with small dialyzable area and poor absorption ability, which is of great significance in slowing down the progress of chronic renal failure. Previous clinical treatment observation also confirmed that the combination of Chinese and western medicine with Chinese medicine colonic enema therapy for the treatment of chronic renal failure has better clinical efficacy, significantly improved the level of serum creatinine, urea nitrogen, and to a certain extent improved endogenous creatinine clearance, delayed the further deterioration of renal function, relieved the patient’s pain, and it is an effective method of treatment of chronic renal failure.