In general, celiac duodenal ulcer can manifest as typical chronic, periodic, rhythmic abdominal pain, i.e., abdominal pain, hunger pain, and nocturnal pain, as well as dyspeptic symptoms such as acid reflux, heartburn, abdominal distension, belching, and loss of appetite, and upper gastrointestinal hemorrhage such as vomiting blood and blood in the stool. Eosinophilic duodenal ulcer, i.e. duodenal ulcer with erosion, refers to the localized inflammatory breakdown with erosion formed when the duodenal mucosa is digested and corroded by gastric acid in gastric juice due to the overproduction of gastric juice or (and) weakening of duodenal mucosal defense function. It can occur at any age, mostly in young adults, and is more prevalent in males. Typical symptoms of duodenal ulcer with erosion are recurrent epigastric pain, which can be dull, distended, burning pain, etc., mostly occurring during fasting. Chronic course, can be up to several years or even decades. Abdominal pain is seasonal, common in autumn, winter, winter and spring; rhythmic, most often in fasting (hunger) attacks, there may be nocturnal pain, abdominal pain can be relieved after eating, and abdominal pain can be relieved after taking acid-suppressing agents.