The symptoms of nodules in the calf may be caused by the following two factors: 1. Chronic muscle strain in the calf leads to sterile inflammation, and the inflammation will lead to the formation of local nodules over time. In this case, pressure on the local nodules will be very obvious pain, and when walking or doing strenuous exercise, the local pain will appear or aggravate. 2, there may be subcutaneous soft tissue swelling formation in the calf, the most common swelling are lipomas, fibroids or sebaceous cysts. If these benign masses do not have infectious inflammation, painful symptoms usually do not occur. Unless it is a sebaceous cyst, if you eat foods that are easily inflamed or stay up late, there is a possibility of infectious inflammation and symptoms of redness, swelling, heat and pain, at which time pressure will be painful, and in severe cases, skin breakdown and pus flow will occur. The subcutaneous swelling can be basically identified by doing local ultrasound.