Pulmonary hypertension is a physiopathologic state of abnormally elevated pulmonary artery pressure. Severe pulmonary hypertension indicates that the patient’s condition has become serious and carries a risk of death if not treated aggressively under the guidance of a medical professional. In general, severe pulmonary hypertension can be treated, but the prognosis is not very good, common treatment methods include drug therapy, surgical treatment, other treatments, etc. 1, general treatment: common such as oxygen therapy, the patient needs to maintain arterial oxygen saturation at 90% or more, while the patient needs to be anti-infective treatment; 2, drug therapy: the patient needs to be guided by a professional doctor, take the appropriate medication for treatment, common such as bosentan, bexarotene and other medications. Commonly, such as bosentan, bezoprost sodium, etc.; 3, surgical treatment: if the effect of other treatments is limited, you can be evaluated by a doctor to consider surgical treatment methods, such as double lung transplantation, cardiopulmonary transplantation, interatrial septal balloon ostomy, and so on. After diagnosis of severe pulmonary hypertension, patients should maintain a good and stable mood in addition to active treatment and regular follow-up as prescribed by the doctor, while patients can exercise moderately according to their own conditions. In addition, patients should avoid going to high altitude areas so as not to aggravate the burden on the body and worsen the condition.