Withdrawal bleeding ends in about 7 days after taking progesterone, but there are individual variations. Progesterone belongs to the progesterone preparation, when women have amenorrhea, can follow the doctor’s instructions to take progesterone for progesterone test, in order to find the cause of amenorrhea. After taking progesterone, withdrawal bleeding will occur in 3~7 days, which usually lasts for about 7 days, but there may be individual differences. Contraindications such as allergy, thrombophlebitis and vascular embolism should be excluded before taking the drug. Adverse reactions such as nausea, dizziness and headache may occur after taking progesterone. When withdrawal bleeding occurs after discontinuation of progesterone, it indicates that the endometrium has been affected by a certain level of estrogen, and when there is no withdrawal bleeding after discontinuation of the drug, further estrogen-progestin sequential testing should be performed to further identify the cause of amenorrhea.