Vaginal bleeding should not occur in the early stages of pregnancy and should be taken seriously. If vaginal bleeding occurs in the first trimester of pregnancy, it is necessary to consult the local hospital immediately and undergo various tests to exclude pre-miscarriage or ectopic pregnancy. Progesterone and human chorionic gonadotropin (HCG) are the first tests that should be performed. Depending on the time of menopause and the level of HCG, an ultrasound will be performed. Low progesterone with vaginal bleeding, need to carry out ultrasound to understand the location of the pregnancy, if the pregnancy is intrauterine, considered to be a pre-eclampsia, given fertility preservation treatment, ultrasound examination of the uterine cavity did not see the fetal sac, does not exclude the ectopic pregnancy and cervical pathology caused by bleeding, must be carried out vaginal examination except for the cervical lesion, if no cervical lesion is seen, a high degree of suspicion of ectopic pregnancy need to be hospitalized for observation, further confirmation of diagnosis and then carry out the appropriate clinical management. The most common clinical symptoms are the aura of pregnancy, which is the most common cause of bleeding. The most common clinical condition is preeclampsia, which is often characterized by low progesterone, which is a hormone secreted by the corpus luteum of the ovary. Progesterone can support the smooth progress of pregnancy, and when the value of progesterone is low, it can trigger miscarriage, and vaginal bleeding can occur, and supplementation of progesterone is very necessary at this time. Abnormal embryonic development, chromosomal abnormalities and other factors can also cause preeclampsia, if the gynecological ultrasound results suggest that there is fluid around the gestational sac, the incidence of preeclampsia is very high, this situation requires hospitalization to preserve the fetus, and in the course of the treatment to observe the changes in the symptoms of abdominal pain and vaginal bleeding. To summarize, when vaginal bleeding occurs in early pregnancy, we should first consider low progesterone, preeclampsia, cervical polyps and other factors, and also pay attention to the exclusion of ectopic pregnancy, we should find out the cause of vaginal bleeding as soon as possible, and consult a doctor in time, to avoid delaying the diagnosis and treatment.