For long-term application of metoprolol tartrate can not be suddenly discontinued, should gradually reduce the dosage until discontinued. Metoprolol tartrate belongs to the β-blocker, has the effect of lowering blood pressure and heart rate, long-term use of sudden discontinuation may cause reflex heart rate increase, blood pressure increase, some people may experience panic, dizziness and other uncomfortable symptoms. According to the actual clinical situation, as well as pharmacokinetic characteristics, gradually reduce the dosage, in general, can be two weeks to reduce the dosage of once, slowly stop the drug. When the application of metoprolol tartrate need to stop, should consult a doctor, and combined with their own dose and the physician’s guidance to reduce the dose, and over a period of time slow and stable discontinuation.