Common side effects of Apatinib include elevated blood pressure and proteinuria, which can be handled by combining antihypertensive drugs and adjusting the dose. 1. Most patients with elevated blood pressure occur about two weeks after taking the drug, and most patients can control their blood pressure by combining with antihypertensive drugs such as nifedipine. 2. Adverse reactions such as proteinuria, bleeding, cardiotoxicity, hepatotoxicity, etc. can be alleviated by reducing the dosage or stopping the drug. 3. Symptomatic treatment of hand-foot syndrome may be indicated, including cleansing of the skin, avoidance of friction and pressure, use of moisturizers or lubricants, topical antibiotic or antifungal therapy if necessary, and consideration of reducing the dose of Apatinib or discontinuing the drug. Occasionally, patients may experience adverse reactions such as acute kidney injury, renal function abnormalities, and nephrotic syndrome. It is recommended that patients go to a regular hospital in time for treatment of discomfort, use Apatinib as prescribed by the doctor, and communicate with the doctor in time when adverse reactions occur.