Hypoglycemia is a clinical syndrome triggered by multiple causes and can occur in diabetic or non-diabetic patients with different etiologies. Hypoglycemia in non-diabetics: Medications are the most common cause of hypoglycemia. All medications used to treat diabetes can cause hypoglycemia, including insulin and insulin-producing agents, and people who take glucose-lowering drugs for weight loss or other purposes have a high probability of developing hypoglycemia. Some substances with other ingredients can also interfere with sugar metabolism to cause hypoglycemia, such as alcohol. Quinolones, pentazocine, quinine, etc. In addition to drugs, some diseases can also cause hypoglycemia, which are in two main categories: insulin-mediated and non-insulin-mediated. Non-insulin-mediated ones commonly include chronic wasting diseases, such as tumors, liver failure, kidney failure, etc. Insulin-mediated hypoglycemia, also known as endogenous hyperinsulinemia, is commonly caused by insulinoma. Hypoglycemia in diabetic patients: both exogenous insulin and endogenous drugs that stimulate insulin secretion can cause hypoglycemia, even severe or fatal hypoglycemia, due to improper use. It should be noted that diabetic patients, especially new onset diabetic patients, do not always have a hyperglycemic state, but have abnormal blood glucose regulation ability, and their blood glucose levels are high and low, so special attention should be paid in medication and ordinary life. Therefore, most hypoglycemia in non-diabetic patients is mostly caused by drug abuse or other diseases, while hypoglycemia in diabetic patients is mainly caused by impaired blood glucose regulation ability or improper treatment.