Lumbar vertebra 5 isthmus collapse protrudes without slipping generally to conservative treatment, including avoiding stooping and weight bearing, wearing a waist cuff, physical therapy, celecoxib and other anti-inflammatory pain medications, and other methods, if necessary, to take surgical treatment. 1. Conservative treatment: avoid prolonged work, avoid stooping and weight-bearing, wear a waist cuff, and carry out appropriate lumbar and dorsal muscle exercise such as swallow fly and three-point support method during the recovery period. During the recovery period, hot compresses, microwaves and other physical therapy can be used to promote local circulation and reduce local edema. If the patient’s pain is severe, anti-inflammatory pain medications such as Loxoprofen and Celecoxib can be used as prescribed by the doctor for symptomatic treatment. 2. Surgery: Surgery can be considered when the conservative treatment is ineffective or the symptoms worsen and seriously affect the patient’s daily life. Lumbar vertebra 5 isthmus collapse protruding without slipping is recommended to go to the hospital in a timely manner, early formal treatment, in order to reduce the adverse effects of the disease.