Twelve-day-old babies always grunting at night can be seen in physiological phenomena, pathological conditions (such as constipation, etc.), the specific intervention measures need to be decided according to the cause. 1. Physiological phenomenon: some babies in the beginning of sleep can appear “humming vigorously”, usually no other abnormal discomfort performance, is a normal physiological phenomenon, without special intervention. Or the night sleep environment environment temperature is high or the blanket is too thick, etc., so that the baby appeared to feel uncomfortable, may appear as the above phenomenon, adjust the indoor temperature or reduce the blanket, etc., as appropriate. 2. Pathological conditions: when the baby several days without stool or stool dryness affect defecation, abdominal discomfort can occur, manifested as the above phenomenon, the need for discretionary use of corkscrew to soften the stool, so that the stool is easy to discharge, but need to pay attention to the movement of the gentle, can be taken orally micro-ecological agents (such as clostridium typhimurium live bacterial powder) to regulate intestinal flora and other therapies. Twelve days of the baby is always humming hard at night may also be related to other reasons, it is recommended to consult a doctor in order to clarify the cause of the disease, standardized treatment. All of the above drugs should be used under the guidance of a physician.