Glutamyl transpeptidase 135 U/L is not necessarily serious and needs to be evaluated in combination with other indicators. Glutamyl transpeptidase is a frequent item in liver function tests. Serum glutamyl transpeptidase comes mainly from the hepatobiliary system, and it is abundant in the kidneys, liver, and pancreas. When bile synthesis in the liver is hyperactive or bile excretion is impaired, serum glutamyl transpeptidase will increase. The normal value of glutamyl transpeptidase ranges from 9 to 40U/L. Glutamyl transpeptidase 135U/L indicates that glutamyl transpeptidase is elevated. gamma Glutamyl transpeptidase can be seen in biliary tract obstructive disease, viral hepatitis, alcoholic hepatitis and other diseases. 1. Biliary tract obstructive disease: primary biliary cirrhosis, sclerosing cholangitis, etc. caused by chronic cholestasis, glutamyl transpeptidase excretion is blocked, with the bile back into the blood, resulting in high serum glutamyl transpeptidase. 2. Viral hepatitis: in acute viral hepatitis, γ-glutamyl transpeptidase synthesis of hepatocytes adjacent to the necrotic area is hyperactive, causing high serum glutamyl transpeptidase. In chronic active hepatitis, the gamma glutamyl transpeptidase test value is often 1 to 2 times higher than the normal value. If elevated for a long time, there may be a tendency of hepatic necrosis. 3. Alcoholic hepatitis: patients with acute alcoholic hepatitis can have a glutamyl transpeptidase level of more than 1000 units/liter. Chronic alcoholic hepatitis patients can also be up to 100 units / liter or so. In alcoholics, glutamyl transpeptidase decreases when they stop drinking. If glutamyl transpeptidase is elevated, it is recommended that the patient should consult a doctor in time to improve the hepatitis virus antibody test, liver function, abdominal ultrasound and abdominal CT and other related examinations, to further clarify the cause of the disease, and systematic diagnosis and treatment, so as to avoid delaying the disease.