Crooked eye fissures are one of the clinical signs of pediatric oculo-ocular-spinal syndrome. There may be cardiovascular malformations, pulmonary, renal, dental and intellectual anomalies, including those where there is no oblique position at all but both eyes are abnormal. Ocular corneal dermatomas, eyelid defects, ptosis, microcornea and microphthalmia, crooked eye fissures, cataracts and other conditions are all possibilities. What causes crooked eye fissures? I. Pathogenesis The etiology of this syndrome is unknown. II. Pathogenesis The 2 cases reported by Henkincl were aunt and cousin with congenital corneal dermatomal tumor at the same time. Zhang Huan reported 2 cases of siblings with congenital keratoderma combined with paraglottic growth, so it is speculated that the occurrence of this syndrome may be related to genetic factors. Gao Baoqing et al. reported one case with complete signs but normal chromosomal examination, and Zhou Daohua et al. reported five cases in 1987, none of which had a family history of congenital inheritance. It may be an embryonic malformation caused by abnormalities of the first and second gill arches and the blood vessels of the spine and eyes. 1. Too many pregnant women affect the development of their children during pregnancy due to various unnoticed things, such as crooked eye fissures. The small eye fissure of a small baby is very much related to drinking during pregnancy. Alcohol is metabolized and excreted at a slower rate in the fetus, causing various injuries to the developing fetus, including fetal malformations, fetal death, growth retardation and behavioral defects, and this small eye fissure may be caused by drinking. 2, the child appears crooked eye fissures, which is related to the body’s chromosomes, during pregnancy, generally for the embryonic development process of gene expression errors, resulting in such a situation, in the survey shows that the children of inbred marriage will produce such a situation. This is why ophthalmoplegia is most often seen in the offspring of consanguineous marriages.