The cure rate of gastrointestinal mesenchymal tumors is related to clinical stage, pathologic staging, and patient status, and cannot be generalized. Gastrointestinal mesenchymal tumors are soft tissue sarcomas originating from Kahal’s mesenchymal cells, which can occur in the entire digestive tract, most commonly in the stomach and small intestine, but also in the extragastrointestinal tract, the omentum, and the mesentery. Gastrointestinal mesenchymal tumors are classified as benign and malignant, most of which are benign if the diameter is less than 2 cm. Gastrointestinal mesenchymal tumors are not highly malignant, but are prone to metastasis and recurrence after surgery. Some studies show that the 10-year survival rate of gastrointestinal mesenchymal tumors is 48%. If the tumor grows in the esophagus and stomach, the treatment effect is relatively good, and the 10-year survival rate is more than 70%; if the tumor grows in the intestinal tract, the 10-year survival rate is only about 17%, and only some of the patients can be cured. Surgery is the most important treatment for gastrointestinal mesenchymal tumors, and other major treatments include interventional drug therapy. Patients should go to the hospital in a timely manner to avoid delaying their condition.