The selection of materials for cranial repair has always been a big issue. The selection of materials for cranial repair is actually very demanding. If the materials are not suitable for one’s own physiological environment, then various serious problems may occur, causing much discomfort, and may even be life-threatening. Because it is necessary to replace the skull with a material that is inserted into the head to reshape the environment of the complete closed cranial cavity, this is actually similar to organ transplantation, except that what is transplanted is not a living organ, but the corresponding repair material. The biggest fear in organ transplantation is tissue incompatibility and rejection, which is also a problem in cranial bone repair. In many clinical cases, the poor tissue compatibility of the material will lead to postoperative rejection reaction, and even finally the scalp is destroyed and the material is exposed. Then some patients ask whether autologous bone can be used for cranial bone repair, and whether the problem of rejection can be solved by using autologous bone! In fact, in the history of the development of cranial bone repair, there have indeed been precedents of using autogenous bone repair, such as using tibia, ribs, shoulder swelling bone, skeleton bone and sternum bone as cranial bone substitutes, but there are also many problems. First of all, there are limited materials to be taken, the human body has only so many bones, each in its own way, and repairing the skull may cause another defect; in addition, it is necessary to open up a second surgical area, which is more traumatic and risky; in many cases, the autogenous bone may be absorbed after transplantation, and the shape of the autogenous bone structure is fixed, which is difficult to mold, and other problems. Therefore, autologous bone repair has long been eliminated. At present, the most ideal cranial bone repair material should be polyether ether ketone PEEK material, the material has quite good tissue compatibility, there will be no rejection reaction. In addition, the properties of PEEK material are very close to those of autologous skull, and it has gradually become the latest trend of cranial bone repair materials.