The severity of cysts in the S5 segment of the liver should be judged according to the specific condition. If the cysts are small and asymptomatic, they are generally not serious; however, if they are combined with hemorrhage, infection, etc., or if they show symptoms of compression, they need further treatment. Liver cysts are common benign space-occupying lesions in the clinic, and their causes may be congenital, trauma, inflammation, etc. Most of the smaller or asymptomatic liver cysts do not need special treatment, and regular review of abdominal ultrasound to observe changes in the condition can be done, and the condition of the cysts in many patients can be stabilized for a long period of time. If the cysts are large in size and have already pressed the surrounding tissues to produce abdominal distension, abdominal pain, etc., surgical treatment should be considered, and most of the cysts should be decapitated or windowed. In addition, patients with intracystic hemorrhage, infection or malignant tendency should be treated promptly. If a cyst is found in the S5 segment of the liver, it is recommended that the patient go to the hospital as soon as possible to have his/her condition evaluated by a professional doctor to decide on the next step of treatment.