Taking venlafaxine for a long time may lead to gastrointestinal reaction, neurological abnormality, drug dependence and so on. 1. Gastrointestinal reaction: most patients will cause gastrointestinal reaction, such as nausea, dry mouth, vomiting, etc., after taking the drug for a period of time, the symptoms will gradually reduce, but some patients will still have serious gastrointestinal reaction after taking the drug for a long time. 2. Nervous system abnormality: patients often take the drug for a long time and lead to dizziness, headache, drowsiness, insomnia and other symptoms, and may even have hemiplegic movement disorder. 3. Drug dependence: If long-term medication will easily lead to drug dependence, can not be stopped at will, otherwise there is a high probability of withdrawal reactions. Common adverse reactions include nausea, dry mouth, headache and sweating. It is prohibited for those who are allergic to this product and the ingredients contained in it. Co-administration with monoamine oxidase inhibitors is prohibited. It should not be used by pregnant and lactating women, or children under 18 years of age. Long-term consumption of venlafaxine should pay attention to observe whether there are adverse reactions, if the adverse reactions are obvious, you need to consult a doctor in time, but avoid arbitrarily stopping the drug on your own.