Hepatogenic diabetes in China is mostly secondary to chronic hepatitis and cirrhosis, and is related to infected viruses. The incidence of hepatitis C virus infection is about 27.6%, and patients have 3 times more abnormal fasting glucose tolerance than non-hepatitis C infection, and 2.5 times more diabetes than non-hepatitis C infection, and about 9%-16% of hepatitis B patients have diabetes. Why are patients with liver disease prone to diabetes? The liver is an important organ that regulates glucose metabolism in the body. It is the place where glycogen is stored and where many glucose-raising hormones are secreted, so liver diseases that reduce the number of liver cells and liver function can cause disorders of glucose metabolism in the body, resulting in hyperglycemia or hypoglycemia. Of course, there is also the presence of insulin resistance, and this problem is more complicated. What are the symptoms of diabetes mellitus in patients with liver disease? In fact, the early clinical manifestations of both ordinary diabetes and hepatogenic diabetes are very recessive, and the typical symptoms of “three more” are not obvious. The incidence of neurological and vascular complications, even in advanced stages, is lower than in type 2 diabetes. If a patient with liver disease, no previous diabetes or family history of diabetes, fasting blood glucose ≥ 7.0 mmol/L, 2 h postprandial blood glucose ≥ 11.1 mmol/L, the diagnosis of hepatogenic diabetes is basically met. Of course, secondary diabetes mellitus and primary diabetes mellitus caused by pituitary, adrenal and thyroid gland diseases should be excluded before diagnosis. The treatment should take into account both liver damage and diabetes, and the primary liver disease should be treated while the blood sugar is under control. First of all, it is a matter of diet. Because the nutrition of patients with liver disease must be ensured, and at the same time to avoid further damage to the liver from various drugs. The diet should be determined according to different body weight and labor status, with carbohydrates as the main ingredient together with a certain amount of protein and vegetables, and it is best to seek guidance from a doctor on the specific ratios. In principle, oral hypoglycemic drugs are prohibited, and insulin should be used as early as possible, not only to effectively lower blood sugar, but also to facilitate liver cell repair and recovery of liver function. The use of insulin should be in line with the physiological needs of a person’s three meals per day, and the combination of short-acting insulin plus medium-acting insulin should be used to control post-prandial glucose, and medium-acting insulin to control basal glucose. The dose of insulin will be adjusted from small to large according to the change of blood glucose monitoring. During the course of insulin use, at least 7 blood glucose measurements a day every month: before breakfast and 2 hours after meals; before and 2 hours after Chinese meals; before and 2 hours after dinner; and before going to bed. This way you can be sure that the insulin dose you are using is appropriate.