Painful thyroid nodules may be caused by intra-nodal hemorrhage, subacute thyroiditis, thyroid cancer and other diseases, which usually need to be treated, and it is recommended to consult a doctor in time. 1. Intra-nodal hemorrhage: If the amount of bleeding is small, medication can be given to stop the bleeding; if the amount of bleeding is large enough to cause compression symptoms, immediate surgery is needed. 2. Subacute thyroiditis: a self-limiting disease, only symptomatic treatment can be used, such as pain symptoms can be used ibuprofen and other drugs to relieve pain, the symptoms of severe cases can be treated with prednisone. 3. Thyroid cancer: when thyroid nodules develop into thyroid cancer, pain may occur; at this time, timely surgical resection is needed, and if necessary, combined with radiotherapy, chemotherapy and other ways of comprehensive treatment. It is recommended to go to the hospital when there is a little pain in the area of thyroid nodule, and treat it under the guidance of the doctor.