Hypo-differentiated cancer is generally based on the degree of cell differentiation, and generally the lower the degree of differentiation, the more malignant it may be, but it is not possible to judge whether it is advanced or not based on the degree of differentiation. Of course, most of the low-differentiated cancers may belong to the middle or middle-late stage. Whether a poorly differentiated cancer is advanced or not depends on the size of the lesion and whether it has metastasized to other parts of the body. Generally, according to the different degrees of cell differentiation, it is divided into highly differentiated, moderately differentiated, poorly differentiated and undifferentiated cancers. Hypo-differentiated cancer belongs to the type with relatively low differentiation and high malignancy, such as lung hyper-differentiated cancer, esophagus or stomach hyper-differentiated cancer, cervix hyper-differentiated cancer, etc. It is more common. If there is still a chance of surgical treatment for this kind of low-differentiated cancer, patients can have surgery first, and after the surgery, they can cooperate with radiotherapy, targeted drugs and other comprehensive treatments in order to control the development of the disease and prolong the survival period.