Parkinson’s disease is a common degenerative disease of the nervous system in the elderly, and its onset may be related to genetic factors, environmental factors, neurological aging and other factors, and it is a disease arising from the interaction of multiple factors.
1. Genetic factors: Parkinson’s disease has a certain relationship with heredity, although the vast majority of patients are sporadic, but about 10% of patients have a family history of Parkinson’s disease.
2. Environmental factors: The presence of substances in the environment that are similar in molecular structure to the neurotoxin 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP), such as some industrial or agricultural toxins, pesticides, herbicides, ichthammol, trichloroethylene, etc. may also increase the risk of Parkinson’s disease.
3. Neurological aging: Neurological aging leads to degenerative changes in nigrostriatal dopaminergic neurons and progressive decrease in dopaminergic neurons, which may also be one of the causes of Parkinson’s disease.
Parkinson’s disease in the environmental factors, the nervous system aging and other factors together to cause the onset of the disease. And the pathogenesis of the disease, is still unclear. It is suggested that avoiding exposure to environments that may cause the disease may reduce the chance of the disease to some extent.