Toothache combined with sore throat may be caused by wisdom teeth, inflammation of gums or tonsils, angina radiation, etc. Surgical and pharmacologic interventions are feasible. 1. Wisdom tooth eruption: For wisdom tooth eruption, antibiotics such as cefadroxil and analgesic drugs such as celecoxib can be applied, and surgical incision and extraction can be taken as intervention. 2. Inflammation of the gums or throat: when gingivitis, tonsillitis, laryngitis and other diseases occur, the above symptoms may appear, and can be treated with penicillin and other anti-infective drugs, chlorhexidine gargle gargle and other treatments, and repeated infections can be treated by surgical removal of the tonsils and other treatments. 3. Angina pectoris: When angina pectoris occurs, in addition to the typical pain of pressure and tightness in the precordial area, radiating pain in the teeth and throat may also occur. Sublingual nitroglycerin can be used for treatment, and it is recommended to go to the hospital in time if the pain is not relieved after using the medicine. Cefadroxil, celecoxib and other drugs mentioned above need to be used under the guidance of clinicians, unauthorized use of drugs is prohibited; the emergence of toothache combined with sore throat, it is recommended to go to the hospital in a timely manner.