Metformin mainly refers to metformin drugs, and nifedipine extended-release tablets can be eaten together, the two have different effects, and generally do not interact. 1. Metformin drugs: hypoglycemic drugs, mainly used for diabetic patients, play a role in lowering blood sugar. Overdose may lead to too rapid a drop in blood sugar levels and hypoglycemia. 2. Nifedipine extended-release tablets: Nifedipine extended-release tablets are calcium channel blockers, mainly used in patients with hypertension to reduce blood pressure, but also used to relieve angina. Improper use may lead to situations where blood pressure is lowered too quickly. Although these two drugs used together will not have a mutual effect, they should be used reasonably under the guidance of a doctor to avoid delays or discomfort.