Spironolactone half a tablet a day is a small dose, and when taken continuously for two years, it does not cause serious adverse effects in most patients. To assess whether spironolactone is harmful, you can periodically go to the hospital to review the indicators to determine whether there are any adverse drug reactions. Spironolactone is a potassium-preserving diuretic with an antagonistic aldosterone effect, commonly used for edema caused by hypertension or other diseases, long-term application of this drug may lead to hyperkalemia, so it is usually used in conjunction with furosemide. Spironolactone half a tablet a day for two years, if the condition requires is no problem, but this long-term use is generally to be used in conjunction with furosemide, a class of potassium diuretics, to prevent the occurrence of hyperkalemia. And attention should be paid to regular monitoring of electrolytes during the use of medication. In addition to the common adverse effects of hyperkalemia, spironolactone may also cause gynecomastia, female hair growth, menstrual disorders, nausea and vomiting gastrointestinal discomfort. Spironolactone should be used with caution in the presence of hepatic or renal insufficiency, anuria with acidosis, and menstrual disorders. Hyperkalemia patients are prohibited. Whether patients are suitable for the application of spironolactone and whether long-term use of the drug is required, it is recommended to listen to the guidance of professional doctors.