To determine the age of a person, we mainly rely on the two parts of the body exposed to clothing – the face and hands. It is often heard that “the hands are the second face of a person”. The importance of facial rejuvenation has now become an everyday occurrence, with the widespread use of skin care cosmetics and cosmetic surgery. However, daily exertion and chemical exposure make hands more prone to aging than the face, and hand rejuvenation is still far from being as important as it is for the face. Therefore, the appearance of the hands will reveal a person’s true age more accurately than the face. Fat transfer to the hands, performed for states such as dryness and sagging skin, can help greatly in overall rejuvenation by giving a person smooth, full hands, thus hiding their true age. As we age, the fat in the hands gradually shrinks, causing the backs of the hands to become dry and wrinkled, resulting in wrinkles, exposed veins and tendons, and an aged appearance. Fat transfer to the hands can help restore the fat distribution to the hands when they were younger. The fullness of the fat gives the back of the hands a smoother and fuller contour, causing wrinkles that have formed to lighten or disappear. In addition, fat grafting can conceal the visible vein exposure and tendon and bone contours on the back of the hands, providing a rapid and dramatic rejuvenation of the hands. Because of the importance of hand function, there was then concern that fat grafting would affect the function of the hands before it was done. In fact, in over 20 years of clinical practice, fat grafting to the hands has been proven to be a safe and effective procedure. The fat on the back of the hand is divided by fascia into 3 separate layers. In the outermost layer of fat, there are no anatomical vessels or nerves, and the grafted fat is mainly injected into this layer. Therefore, the needle piercing this layer of fat does not damage any blood vessels or nerves, and the fat does not enter the blood vessels causing fat embolism. Therefore, fat grafting to the hand is very safe and only about 10% of patients experience temporary abnormal sensation of the back of the hand after the procedure, which basically does not affect the sensory and motor functions of the hand.