The pain in the lower right side of the stomach while running is considered to be related to strenuous exercise, intestinal spasm, acute appendicitis, intestinal obstruction, etc., which can be treated with medication as prescribed by the doctor, and surgical treatment if necessary. 1. Strenuous exercise: when some people suddenly exercise strenuously, it can cause intestinal spasm, which is manifested as pain in the lower right side of the stomach when running. Usually, it can be relieved after proper rest and no special treatment is needed. Severe pain can be prescribed with resorcinol, pivacyl bromide and other antispasmodic pain relievers, some patients can also be prescribed with dimethylsiloxane to reduce gastrointestinal gas. 2. Acute appendicitis: when the runner suffers from acute appendicitis, it can be manifested as pain in the lower right side of the stomach. For those who are diagnosed with the disease, clinical priority is given to laparoscopic surgery or open surgery to remove the lesion and prevent the appendix from suppuration or perforation. Some patients can also take conservative treatment first, can apply penicillin, cefixime and other antibiotic treatment. 3. Intestinal obstruction: the disease can also cause some patients to run with pain in the lower right side of the stomach. Patients with intestinal obstruction usually need to cooperate with the doctor to carry out gastrointestinal decompression therapy, but also through intravenous infusion to correct the water electrolyte disorders, acid-base imbalance. Some patients with severe conditions can be treated with surgery such as simple de-obstruction surgery, intestinal resection and intestinal anastomosis. It is recommended that people who run with pain in the lower right side of the stomach should consult a doctor for examination in order to clarify the cause of the disease and then follow the doctor’s instructions for treatment, and should not use drugs indiscriminately on their own to prevent aggravation of the condition.