There are many differences between oral rotavirus vaccine and pentavalent rotavirus vaccine, such as the type of prevention, method of use, duration of protection, and price of the drug. 1. Types of prevention: oral rotavirus vaccine can prevent one type of rotavirus, while pentavalent rotavirus vaccine can protect against five types of rotavirus. 2. Method of use: Rotavirus vaccine needs to be taken only once, while pentavalent vaccine needs to be taken in three doses. 3. Duration of protection: The oral rotavirus vaccine protects for about one year, while the pentavalent rotavirus vaccine protects for about seven years. 4. Price of medication: The oral rotavirus vaccine is usually free, and the pentavalent vaccine costs about 300 yuan. Vaccination should be based on the child’s specific situation, follow the doctor’s advice to take the appropriate vaccine.