Cholangiocarcinoma with distant metastasis and severe symptoms/complications is more serious, and its severity is related to the site of occurrence and pathologic pattern. Cholangiocarcinoma tumors grow slowly and often infiltrate along the wall of bile ducts, and are less likely to develop distant metastasis, but if distant metastasis occurs, it will lead to secondary malignant tumors. According to the site of tumor occurrence, there are intrahepatic cholangiocarcinoma, hepatoportal cholangiocarcinoma (upper bile duct cancer), middle bile duct cancer, and distal cholangiocarcinoma. Among them, hepatoportal cholangiocarcinoma is the most common accounting for 50%~75%. Among the histologic types in cholangiocarcinoma pathology, adenocarcinoma accounts for more than 95%, but the less common poorly differentiated and undifferentiated carcinomas are more malignant and usually occur in upper-segment cholangiocarcinomas. The severity of cholangiocarcinoma is related to the stage, site of onset, symptoms, etc. If distant metastasis has occurred, it is advanced stage, combined with severe jaundice, digestive discomfort and other symptoms, which is very serious at this time. It should be noted that if one finds symptoms such as bile duct obstruction, enlarged gallbladder, weight loss, poor appetite, etc., one should go to the hospital in time for relevant examinations, such as CT, to determine whether distant metastasis has occurred.