Thick, yellow toenails that hurt when touched can be caused by fungal or bacterial infections and require antifungal and antibacterial treatment, and sometimes nail extraction. If a fungal infection occurs, the toenails will be thick and yellow, called gray nails, and the toenails will have gaps, requiring antifungal treatment, including oral antibacterial drugs and topical antifungal drugs. Commonly used medications include itraconazole capsules and ketoconazole ointment. After the occurrence of gray nails, there may be complications of inguinitis, at this time there will be pain, inguinitis is a disease caused by bacterial infection, so antibacterial treatment is needed, can be used externally with antibacterial ointment, if the embedded nails, the need for nail extraction, erythromycin ointment, mupirocin ointment and so on. It is recommended that patients go to the hospital to be able to determine the cause, and then the appropriate treatment can be carried out, the drug should be applied under the guidance of the doctor.