Anti-SSA antibody positivity is mainly seen in dry syndrome, and the positivity rate can reach 40%-95% in patients with dry syndrome. If the patient’s serum is positive for SSA, anti-SSB antibody and anti-ANA antibody, it is more significant for the diagnosis of desiccation syndrome. In this case, further judgment can be made by combining the clinical symptoms of the patient and the biopsy of the labial gland. However, anti-SSA antibody positivity is not only seen in dry syndrome, but also in other immune system diseases, such as systemic lupus erythematosus, scleroderma, inflammatory diseases, rheumatoid arthritis, alcoholic liver disease and viral hepatitis. If the anti-SSA antibody is weakly positive, it only indicates the presence of immune system diseases, but cannot be used to make a definite diagnosis. It is necessary to combine the clinical manifestations of the patient and other antibody test results for a comprehensive judgment. Therefore, patients are required to undergo relevant tests, such as antinuclear antibody titers, serology or urine tests, for comprehensive diagnosis and timely treatment.