Checking urine leukocytes 1 plus sign suggests that there is a mild urinary tract infection. It may be caused by urethritis, cystitis, pyelonephritis and so on. It is recommended to drink more water, and if necessary, give levofloxacin tablets, amoxicillin capsules and other drugs for treatment. 1. Urethritis: urine white blood cells a plus may be caused by urethritis, mild inflammation is recommended to drink more water, or under the guidance of the doctor to take antibiotics such as ofloxacin and other drugs for treatment. 2. Cystitis: Cystitis due to lower urinary tract infections can also occur urine leukocytes 1 plus. Patients may also experience symptoms such as frequent urination, urgency, and painful urination. You can take levofloxacin tablets and other drugs as prescribed by the doctor for treatment. 3. Pyelonephritis: Pyelonephritis is caused by upper urinary tract infection, and the patient experiences symptoms of urinary tract irritation, which may also lead to high fever and lumbago. You can take amoxicillin capsules and other drugs for treatment. It is recommended that patients with 1 plus urine leukocytes, timely to the hospital, under the guidance of the doctor to improve the relevant examination, clear causes, active treatment, avoid self medication, so as not to cause adverse effects.