Patients with ascites can consider etiologic treatment, puncture and drainage, surgical treatment and other ways to relieve when drug treatment is ineffective. 1. Etiological treatment: patients with hepatitis B virus infection can be treated with drugs such as entecavir; patients with cirrhosis can be treated with drugs such as reduced glutathione and adenosylmethionine to protect the liver; patients with autoimmune liver disease can be considered to use drugs such as prednisone to intervene. 2. Puncture and drainage: puncture and drainage in the abdominal wall to release ascites, and supplemental albumin treatment is also needed if necessary. 3. Surgery: for patients with ascites caused by elevated portal vein pressure in cirrhosis, transjugular intrahepatic portosystemic shunt can be considered to reduce the portal vein pressure and relieve the ascites; patients with ascites caused by hepatocellular carcinoma need to consider surgical resection of the tumor tissue. In addition, patients with ascites should limit the intake of water and sodium in daily life. When the treatment of ascites is ineffective, it is recommended to go to the hospital for medical consultation, so that the professional doctor can make judgment and formulate reasonable treatment plan.