Congenital adrenocortical hyperplasia in infants should be corrected by correcting water and electrolyte disturbances, long-term oral treatment with fludrocortisone and hydrocortisone, and surgical treatment for female hermaphroditism.
Congenital adrenocortical hyperplasia is one of the more common autosomal recessive disorders due to congenital defects in the enzymes required for corticosteroid synthesis. Insufficient cortisol synthesis negative feedback promotes the secretion of adrenocorticotropic hormone, leading to adrenal cortical hyperplasia and secretion of excessive 11-deoxycortisol and adrenal androstenedione, etc. It is classified into salt-loss, simple masculinized, and atypical types.
1. Pharmacological treatment: For children with salt-loss type and simple masculinized type, glucocorticoids should be given as soon as the diagnosis is made, which can be combined with long-term treatment of oral saline corticosteroids such as fludrocortisone and glucocorticoids such as hydrocortisone. Intravenous hydrocortisone can be given for severe salt-loss type. At the same time to correct water, electrolyte disorders, available saline and sodium bicarbonate solution.
2. Surgical treatment: male children do not need surgical treatment. Female children with hermaphroditic malformation should have partial clitoridectomy or orthopedic surgery when they are 6 months to 1 year old.
Infants with congenital adrenocortical hyperplasia should go to the hospital in time and be treated under the doctor’s guidance. The above drugs should be used according to the doctor’s prescription.