Rheumatoid arthritis can not be diagnosed only based on laboratory indicators, need to be combined with clinical manifestations, laboratory tests, imaging tests to make a comprehensive judgment, commonly used blood, inflammatory markers, autoantibodies and other laboratory indicators, X-ray examination, rheumatoid nodule biopsy, MRI examination, and so on. 1. Laboratory tests: blood changes are related to the degree of disease activity, and blood sedimentation and C-reactive protein are often elevated, which are the main indicators reflecting the degree of disease activity. Rheumatoid factor, anti-citrullinated protein antibody and other autoantibodies are important indicators for diagnosing rheumatoid arthritis. 2. X-ray examination: X-ray film of both hands, wrist joints and other affected joints is very important for the diagnosis of rheumatoid arthritis, staging of arthropathy and monitoring the evolution of lesions. 3. Biopsy of rheumatoid nodules: there are typical pathological changes, such as synovitis, vasculitis, rheumatoid nodules. 4. MRI examination: MRI examination can distinguish articular cartilage, synovial membrane and subchondral bone tissue very well, which is helpful to find early joint destruction. It is recommended that patients go to regular hospitals to clarify whether they have rheumatoid arthritis through a variety of laboratory and imaging tests, and follow the doctor’s instructions.