Fear of cold and easy fatigue may be a precursor of cancer, but cancer precursors are more complex and do not necessarily manifest only with fear of cold and easy fatigue, so fear of cold and easy fatigue may also be a precursor of other diseases. Fear of cold and easy fatigue may be one of the symptoms of depression, accompanied by lack of interest, lethargy, and reduced quality of life and work. Severe anemia, heart disease, endocrine diseases may also make patients afraid of cold and easily fatigued, and early precursors of major diseases such as cancer and tumor may also make patients afraid of cold, so afraid of cold and easily fatigued is one of the clinical symptoms, and different diseases may have this symptom. When a patient develops coldness and fatigue, he/she should consult a doctor in time. It may be necessary to make a diagnosis and differential diagnosis under the collaboration of multidisciplinary experts, and to find the exact cause of the disease and then carry out corresponding treatment. If it is cancer, early detection and treatment can lead to a better prognosis. In case of depression or other major organic lesions, early detection, early treatment and early intervention can also lead to a better prognosis, and patients should not take tonic drugs first, and the fundamental measure is to find the exact cause and then treat the cause.