Creatinine 124μmol/L is generally not serious if it belongs to physiological increase, and can be returned to normal by removing the causative factors; if it belongs to the elevation caused by acute kidney injury in the pathological increase, it is generally not serious, and can be returned to normal; if it is a chronic increase, it is more serious, and can not be returned to normal in general. 1. Physiological elevation: generally not serious and no special treatment is needed. For example, after strenuous exercise, eating a lot of meat food, too much emotional stress and anxiety, etc. may cause high creatinine, but physiological factors cause high creatinine will not affect renal function and renal excretion, so it is not serious, and can be returned to normal by removing the triggering factors, but it is recommended to have regular review to assess the renal function. 2. Pathological increase (1) If creatinine 124μmol/L is pathologically elevated, the excretion of renal function has been changed. If the increase is acute, such as diarrhea, infection, etc. caused by a transient increase in creatinine, after removing the cause of the disease and symptomatic treatment, generally can be recovered, so it is not serious. (2) If the elevated creatinine is chronic, i.e. chronic renal failure, it generally cannot be restored to normal, and if it is not treated in time, further aggravation of the condition may also develop into uremia. If the creatinine is found to be elevated, it is recommended to go to the hospital in time to find out the cause and follow the doctor’s instructions to standardize the treatment.