The cause of high creatine kinase levels may be a physiological condition or a pathological one. In evaluating its cause, it is necessary to combine it with other indicators, such as troponin, for a comprehensive judgment. In the case of physiological creatine kinase elevation, it can be seen after strenuous exercise and in patients who have given birth. Some therapeutic measures can also increase creatine kinase, including cardiopulmonary resuscitation, cardiac compressions, pacemakers, cardiac catheterization, etc. Creatine kinase can also be increased. The use of medications, including antibiotics, dexamethasone, pain medications, and anesthetic drugs, can also increase creatine kinase. For pathological increases, such as in patients with coronary artery disease and myocardial infarction, it is often necessary to look at creatine kinase as well as creatine kinase isoenzymes and troponin for a comprehensive determination. In patients with cerebrovascular accident, myotonic dystrophy, dermatomyositis, and myocarditis, elevated creatine kinase may also be seen.