Gastric sinus leukoplakia is a localized white change of mucous membrane seen under endoscopy, which is a manifestation of gastric sinusitis, and may also appear because of cancer. If it is caused by cancer, surgery is needed, but if it is caused by chronic gastritis, surgery is usually not needed. If the leukoplakia of the gastric sinus is caused by cancer, it needs to be treated by surgical resection, and also needs to be assisted by radiotherapy and chemotherapy in the later stages of treatment. If the leukoplakia of gastric sinus is caused by chronic gastritis and other factors, surgery is usually not needed. It is recommended to follow the doctor’s instructions oral omeprazole, teprenone and other treatments, usually avoid spicy and stimulating food, eat more vegetables and fruits. If there is a white spot in the gastric sinus, it is necessary to consult a doctor in time and carry out a pathological examination to determine the nature of the disease, and then under the guidance of a professional physician treatment.