Estrogen is an important hormone that promotes the development of female secondary sex characteristics and the normal functioning of the female reproductive system, and ensures that the female uterus, breasts, pelvis and other reproductive organs are healthy and play normal physiological roles. Once estrogen is high, it may cause breast swelling and pain, areola expansion, thickening of the uterine lining, and even uterine fibroids, which may also have the probability of cancerous changes if left untreated. In the later stages of the disease, it can cause a variety of neurological discomforts. High estrogen in women, which mostly occurs during women’s reproductive age and early menopause, is a prevalent condition for modern women with stressful work and life. Especially for girls who come to puberty too early and women who habitually use hormonal drugs and foods, when they enter their reproductive years and menopause, they will experience pituitary and gonadal hyperactivity, causing endocrine disorders and consequent pathologies. For those who have long-standing irregular menstruation with dysmenorrhea and habitual breast swelling and pain, attention needs to be paid to the fact that it is caused by high estrogen secretion. In the middle of the course of the disease, stress relief, emotional detoxification, and vitamins to regulate the absorption of micronutrients and the reconstruction and recovery of the nervous system can help to reduce estrogen levels and improve the health of the gonads. High estrogen has become a relatively common condition that requires special attention during medical checkups, and it is important to take advantage of the initial treatment in order to have the possibility of a complete cure.