Urine protein a plus only indicates an increase in the protein content in the urine, mostly caused by the increased permeability of the kidneys. A plus urine protein is only a mild manifestation of proteinuria, mainly related to the following factors: First, the influence of physiological factors, mainly the consumption of a large amount of protein-rich food or strenuous exercise in a short period of time, thus prone to physiological urine protein, but will soon return to normal; Second, the influence of pathological factors, that is, a continuous increase in urine protein, may have some relationship with kidney diseases. In addition, diabetes mellitus, multiple myeloma, tumors, and hypertension can cause a persistent increase in pathological urine protein. Although the symptoms of a plus sign are not too serious, the consequences of allowing it to develop are very serious. It is important to clarify whether a plus is pathological or physiological when urine protein appears, so that appropriate treatment can be taken.