Progesterone insufficiency in non-pregnancy can lead to menstrual disorders, hydroelectrolyte disorders, and endocrine disorders; progesterone insufficiency in pregnancy manifests itself in easy miscarriage. 1. When not pregnant: progesterone insufficiency includes menstrual disorders, water electrolyte disorders, and endocrine disorders. (1) Insufficient progesterone secretion can lead to poor secretion response of the endometrium, thus causing frequent menstruation, which is generally manifested as shortening of the menstrual cycle. (2) Progesterone has the effect of promoting the excretion of water and sodium, and when progesterone is reduced, it can lead to water and sodium retention and the formation of edema. (3) Endocrine disorders: progesterone has a negative feedback regulation effect on the hypothalamus, when progesterone decreases, it will promote the hypothalamus to secrete gonadotropins, leading to endocrine disorders. 2. During pregnancy: As progesterone deficiency may lead to miscarriage, the clinical manifestation is the symptom of vaginal bleeding and abdominal pain after menopause. Therefore, when progesterone decreases, one should go to the hospital for consultation in time to clarify the cause of the decrease in progesterone, and under the guidance of the doctor, treatment should be carried out.