The difference between the four-shot method and the five-shot method of rabies vaccine is that the number of times of vaccination is different, but the immunization effect is the same. Rabies vaccine four-shot method and five-shot method can play a very good role in immunization, effective prevention of rabies, just in this kind of time the number of times of vaccination is different, rabies vaccine four-shot method is mainly in accordance with the 2-1-1 program of vaccination, respectively, was bitten by the 0, 7, 21 days of the inoculation, the first inoculation needs to be left and right arm each one, a total of four needles to be inoculated. The five-dose rabies vaccine is administered on days 0, 3, 7, 14 and 28, requiring a total of five doses. Both the four-dose and five-dose methods of rabies vaccination can produce effective immunity, so it is sufficient to be vaccinated according to the doctor’s instructions, and it is necessary to complete the whole process of vaccination, whether it is the four-dose method or the five-dose method.