Crohn’s disease has a genetic predisposition, and the exact rate of inheritance has not been determined. Crohn’s disease is a disorder of immune dysfunction leading to multisegmental lesions throughout the digestive tract and is a type of inflammatory bowel disease. The incidence rate of first-degree relatives of patients with Crohn’s disease is significantly higher than that of the general population, the incidence rate of spouses of patients does not increase, and its incidence rate of monozygotic twins is significantly higher than that of dizygotic twins, so there is a certain hereditary predisposition to Crohn’s disease in view of these characteristics. Through the research on genetic aspects in recent years, some gene mutations are related to the onset of Crohn’s disease, which also confirms that Crohn’s disease will have the possibility of heredity. However, Crohn’s disease has a clear genetic tendency in Caucasians, but not in yellow people, that is, the possibility of inheritance of yellow people is relatively small compared to white people. The specific inheritance rate is still inconclusive. In addition to genetic predisposition, Crohn’s disease is associated with environmental factors such as alcohol consumption, smoking, hygiene and infectious factors such as chronic intestinal infections and immune disorders.