The treatment of monoclonal immunoglobulin deposition disease in general consists of two directions, the first is the treatment of renal disease and the second is the treatment of anti-B cell clones.
Monoclonal immunoglobulin deposition disease is a clonal disease due to abnormal B cells or plasma cells, which produce monoclonal immunoglobulin that damages the kidneys through several mechanisms.
For the treatment of renal disease, it is necessary to improve the renal biopsy and choose the appropriate modality according to the pathological results. Glucocorticoid (methylprednisolone) and immunosuppressant (cyclophosphamide) can be chosen to inhibit immune response, plasma exchange, and renal transplantation, etc. In addition, renin-angiotensin-aldosterone receptor antagonist (valacyclovir, benazepril) can also be chosen to lower urinary protein treatment.
Treatment of anti-B-cell clones includes autologous stem cell transplantation, chemotherapy and targeted therapy.
Specific treatment options need to be based on the specific type of monoclonal immunoglobulin and the deposition of the site of comprehensive consideration, it is recommended that the patient to the regular hospital in time, and actively cooperate with the doctor’s treatment. The medication should be used in accordance with the doctor’s instructions, do not self-medication.